TMB | CAS 54827-17-7
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TMB · CAS 54827-17-7 · C16H20N2. UNII 3B3T5CB8EO. Melting Point: 334 to 336 °F (NTP, 1992); Melting Point: 168.5 °C; Vapor Pressure: 0.0000005 [mmHg].
Identification
| CAS Registry Number | 54827-17-7 |
|---|---|
| PubChem CID | 41206 |
| Molecular formula | C16H20N2 |
| IUPAC name | 4-(4-amino-3,5-dimethylphenyl)-2,6-dimethylaniline |
| UNII (FDA) | 3B3T5CB8EO |
Computed Descriptors
| Molecular Weight | 240.34 |
|---|---|
| XLogP3 | 3.6 |
| Hydrogen Bond Donor Count | 2 |
| Hydrogen Bond Acceptor Count | 2 |
| Rotatable Bond Count | 1 |
| Exact Mass | 240.162648646 |
| Monoisotopic Mass | 240.162648646 |
| Topological Polar Surface Area | 52 |
| Heavy Atom Count | 18 |
| Formal Charge | 0 |
Physical & Chemical Properties
| Melting Point | 334 to 336 °F (NTP, 1992) |
|---|---|
| Melting Point | 168.5 °C |
| Vapor Pressure | 0.0000005 [mmHg] |
Physical description & handling notes
- 3,3',5,5'-tetramethylbenzidine appears as pale yellow crystals or off-white powder. (NTP, 1992)
- Pale yellow or off-white solid; [CAMEO] White or light yellow solid; [MSDSonline]
- less than 1 mg/mL at 68 °F (NTP, 1992)
- When heated to decomp it emits toxic fumes of /nitrogen oxides/.
- 175.7 Ų [M+H]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID5026120]
- 162.4 Ų [M]+ [CCS Type: DT; Buffer gas: N2; Ionization: APCI+; Dataset: TOXCAST; Source Identifier: DTXSID5026120]
Regulatory Status
| GHS notification summary | 2.8% (2 / 72) |
|---|
GHS Hazard Classification
| GHS notification summary | 2.8% (2 / 72) |
|---|---|
| Reported hazard statements | H302 (29.2%), H315 (94.4%), H319 (94.4%), H335 (93.1%), H341 (19.4%) |
This chemical does not meet GHS hazard criteria for 2.8% (2 of 72) of reports.
H302 (29.2%): Harmful if swallowed [Warning Acute toxicity, oral]
Documented Uses
- Used as a clinical reagent for testing blood; [HSDB]
- Clinical reagent for testing blood
- [1,1'-Biphenyl]-4,4'-diamine, 3,3',5,5'-tetramethyl-: ACTIVE
- …/PRC: USED/ AS SENSITIVE SUBSTITUTE FOR BENZIDINE IN DETECTION OF BLOOD… IN VIEW OF ITS CLOSE RELATIONSHIP TO…CARCINOGENS, HOWEVER, MORE COMPREHENSIVE BIOLOGICAL TESTS SEEM DESIRABLE BEFORE IT IS ACCEPTED AS SAFE FOR WIDESPREAD LABORATORY USE.
- THE DERIVATION & SYNTHESIS OF 3,4,3',5'-TETRAMETHYL BENZIDINE ARE DESCRIBED.
- Colorless, endogenous or exogenous pigment precursors that may be transformed by biological mechanisms into colored compounds; used in biochemical assays and in diagnosis as indicators, especially in the form of enzyme substrates. Synonym: chromogens (not to be confused with pigment-synthesizing bacteria also called chromogens).
Synonyms
54827-17-7; 3,3',5,5'-TETRAMETHYLBENZIDINE; 3,3',5,5'-Tetramethyl-[1,1'-biphenyl]-4,4'-diamine; 3,5,3',5'-Tetramethylbenzidine; DTXSID5026120; 3B3T5CB8EO; COLORBURST BLUE; 3,3',5,5'-Tetramethyl-(1,1'-biphenyl)-4,4'-diamine; (1,1'-Biphenyl)-4,4'-diamine, 3,3',5,5'-tetramethyl-; POTASSIUM-BLUE MAX; 3,3',5,5'-Tetramethyl(1,1'-biphenyl)-4,4'-diamine; DTXCID406120; [1,1'-Biphenyl]-4,4'-diamine, 3,3',5,5'-tetramethyl-; 3,3',5,5'-Tetramethyl[1,1'-biphenyl]-4,4'-diamine; tetramethyl benzidine; RefChem:484862
Frequently Asked Questions
What are the CAS number and molecular formula of TMB?
CAS 54827-17-7; molecular formula C16H20N2; molecular weight — g/mol.
What other names is TMB known by?
54827-17-7, 3,3',5,5'-TETRAMETHYLBENZIDINE, 3,3',5,5'-Tetramethyl-[1,1'-biphenyl]-4,4'-diamine, 3,5,3',5'-Tetramethylbenzidine, DTXSID5026120, 3B3T5CB8EO.
Is TMB classified as hazardous?
2.8% of GHS notifications report no hazard classification (2 of 72).
What are the key physical properties of TMB?
Melting Point: 334 to 336 °F (NTP, 1992); Melting Point: 168.5 °C; Vapor Pressure: 0.0000005 [mmHg].
Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.