Tris Base | CAS 77-86-1
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Tris Base · CAS 77-86-1 · C4H11NO3. UNII 023C2WHX2V. Boiling Point: 219-220 °C at 10 mm Hg; Melting Point: 171-172 °C; Solubility: In water, 5.50X10+5 mg/L at 25 °C.
Identification
| CAS Registry Number | 77-86-1 |
|---|---|
| PubChem CID | 6503 |
| Molecular formula | C4H11NO3 |
| IUPAC name | 2-amino-2-(hydroxymethyl)propane-1,3-diol |
| UNII (FDA) | 023C2WHX2V |
Computed Descriptors
| Molecular Weight | 121.14 |
|---|---|
| XLogP3 | -2.9 |
| Hydrogen Bond Donor Count | 4 |
| Hydrogen Bond Acceptor Count | 4 |
| Rotatable Bond Count | 3 |
| Exact Mass | 121.07389321 |
| Monoisotopic Mass | 121.07389321 |
| Topological Polar Surface Area | 86.7 |
| Heavy Atom Count | 8 |
| Formal Charge | 0 |
Physical & Chemical Properties
| Boiling Point | 219-220 °C at 10 mm Hg |
|---|---|
| Melting Point | 171-172 °C |
| Solubility | In water, 5.50X10+5 mg/L at 25 °C |
| Vapor Pressure | 0.000022 [mmHg] |
| Ionization Efficiency | 2.41 |
| Ionization Efficiency | 2.7 |
| Ionization Efficiency | MeCN (80%) |
| Ionization Efficiency | DOI:10.1007/s13361-016-1563-2 |
| Dissociation Constants | 8.08 |
| Dissociation Constants | pKa = 8.07 |
Physical description & handling notes
- Liquid; Large Crystals; Dry Powder; Other Solid
- Solid; [Merck Index] White hygroscopic crystals; [Alfa Aesar MSDS]
- Crystalline mass
- WHITE, CRYSTALLINE POWDER
- SLIGHT, CHARACTERISTIC ODOR
- FAINT, SWEET, SOAPY TASTE
Regulatory Status
| Regulatory & Food Contact | CIR / INCI: Cosmetic ingredients (Tromethamine) -> CIR (Cosmetic Ingredient Review) |
|---|---|
| GHS notification summary | 19.7% (235 / 1192) |
GHS Hazard Classification
| GHS notification summary | 19.7% (235 / 1192) |
|---|---|
| Reported hazard statements | H315 (80.2%), H319 (80.3%), H335 (70.8%) |
This chemical does not meet GHS hazard criteria for 19.7% (235 of 1192) of reports.
H315 (80.2%): Causes skin irritation [Warning Skin corrosion/irritation]
Documented Uses
- Leather Tanning and Processing [Category: Industry]
- Textiles (Printing, Dyeing, or Finishing) [Category: Industry]
- In the synthesis of surface-active agents, vulcanization accelerators, pharmaceuticals. As emulsifying agent for cosmetic creams and lotions, mineral oil and paraffin wax emulsions, leather dressings, textile specialties, polishes, cleaning compounds, so-called soluble oils. Absorbent for acidic gases. Biological buffer.
- Therapeutic Category: Alkalinizing agent
- Use (kg; approx.) in Germany (2009): >500
- Consumption (g per capita; approx.) in Germany (2009): 0.00611
Synonyms
Trometamol; TROMETHAMINE; 77-86-1; Tris(Hydroxymethyl)aminomethane; Tham; Trisamine; 2-Amino-2-(hydroxymethyl)-1,3-propanediol; Tris buffer; Tromethane; Tris-base; Trisaminol; Pehanorm; Talatrol; Tutofusin tris; Tris-steril; Addex-tham
Frequently Asked Questions
What are the CAS number and molecular formula of Tris Base?
CAS 77-86-1; molecular formula C4H11NO3; molecular weight — g/mol.
What other names is Tris Base known by?
Trometamol, TROMETHAMINE, 77-86-1, Tris(Hydroxymethyl)aminomethane, Tham, Trisamine.
What is the regulatory status of Tris Base?
Documented regulatory listings: CIR / INCI: Cosmetic ingredients (Tromethamine) -> CIR (Cosmetic Ingredient Review).
Is Tris Base classified as hazardous?
19.7% of GHS notifications report no hazard classification (235 of 1192).
What are the key physical properties of Tris Base?
Boiling Point: 219-220 °C at 10 mm Hg; Melting Point: 171-172 °C; Solubility: In water, 5.50X10+5 mg/L at 25 °C; Vapor Pressure: 0.000022 [mmHg].
Facts on this page are taken from PubChem (US National Library of Medicine) and Wikidata. Grade-specific data — assay, moisture, particle size, packaging, shelf life — is issued per batch on the COA and is not published here.